Endometrial cancer occurence five years after breast cancer in BRCA2 mutation patient
نویسندگان
چکیده
We recently experienced a case of endometrial cancer 5 years after the diagnosis of breast cancer in a patient with a mutation in the BRCA2 gene. A 55-year-old Korean woman who had a past history of breast cancer in her 50s underwent an operation for endometrial cancer. Final pathology confirmed stage Ia, and no adjuvant treatment was performed. After surgery, considering her history of sequential cancer occurrence, genetic counseling was offered. The result showed the BRCA2 variation of unknown significance mutation. This is the first case report of sequential cancers (endometrial and breast) in a patient with a BRCA2 mutation among a Korean population.
منابع مشابه
Minor role of BRCA2 mutation (Exon2 and Exon11) in patients with early-onset breast cancer amongst Iranian Azeri-Turkish women
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Background and purpose: Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer. Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of...
متن کاملجهش های ژنتیکی جدید در ژن های اصلی سرطان پستان (BRCA1/BRCA2) در زنان ایرانی مبتلا به سرطان پستان زودرس
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متن کاملComment on: Endometrial cancer occurrence five years after breast cancer in BRCA2 mutation patient
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. We read with great interest the article by Oh et al. [1]. First of all, BRCA2 mutation of the present case is unclassified variants (UVs). The results of the BRCA1/2 genetic test is divided into mutations detected, not-detected and UVs mutations. UVs are ref...
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